| Autor: |
Frazier, Théo, Murail, Pauline, Giraud, Francis, Artola, Alain, Dallel, Radhouane, Anizon, Fabrice, Moreau, Pascale |
| Předmět: |
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| Zdroj: |
Synthesis; Jul2024, Vol. 56 Issue 13, p2093-2099, 7p |
| Abstrakt: |
This article discusses the optimization of the synthesis of pyridin-2(1 H)-ones, which have potential as pain-relieving compounds. The researchers aimed to discover novel analgesic compounds that are more effective and safe for managing chronic pain. They conducted a study to improve the synthesis of a specific compound and prepared analogues to evaluate their efficacy in preventing mechanical allodynia in a rat model. The text provides a series of procedures for the synthesis and purification of various compounds, along with characterization data such as melting point and spectroscopic data. The document also briefly mentions a behavioral study conducted on rats to assess the effects of the synthesized compounds on mechanical hypersensitivity. [Extracted from the article] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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