| Autor: |
Ünçe, Melek, Diniz, Gülden, Aköz, Gamze, Ekin, Zübeyde Yıldırım, Sayhan, Sevil, Yardım, Serdar, Salimoğlu, Semra |
| Předmět: |
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| Zdroj: |
European Journal of Breast Health; Apr2019, Vol. 15 Issue 2, p125-129, 5p |
| Abstrakt: |
Objective: Breast cancer is the most common cancer among women worldwide. Adenine thymine-rich interactive domain 1A (ARIDIA) is a tumor suppressor gene involved in chromatin remodeling and it encodes the ARIDIA protein. Recent studies have shown the loss of ARIDIA protein expression in different carcinomas may have a prognostic significance. In the present study, we aimed to evaluate the interactions between ARIDIA loss and molecular subtypes of breast carcinomas. Materials and Methods: ARIDIA expressions were studied in 292 formalin-fixed, paraffin-embedded breast carcinoma specimens and its association with different pathological and clinical parameters was evaluated. Results: Loss of ARIDIA expression was detected in 123 cases. There was no statistically significant association between ARID-1A expression and molecular subtype of breast carcinomas (p=0.110) or HER2 amplification (p=0.909). Contrarily, there was a significant association between ARIDIA expression and presence of estrogen (p=0.047) or progesterone receptors (p=0.023). Besides a statistically significant relationship was found between loss of ARID1A, and the presence of both in situ component (p=0.016) and lymph node metastasis (p=0.001). Conclusion: In this study, we have demonstrated that loss of ARID1A expression positively correlates with hormone receptor status as well as tumor aggressiveness. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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