| Abstrakt: |
A description is given of the electron microscopic appearance of skin changes taking place in the blister of pemphigoid. No unusual information has been obtained and no specific intracellular changes are seen. The dermo-epidermal junction is damaged by the oedematous changes which eventually cause its cleavage. Obliteration of the fine structure of the dermal fibrous tissue suggests the precipitation or alteration of the ground substance; the collagen probably remains in a very fine fibrillar form. Elastin is not seen. There is intercellular oedema of the epidermis, and the epidermal cells show increase of cytoplasmic detail—i.e., an increase in granular (RNA) and vesiculate material, increase in the number and robustness of mitochondria which, presumably when the cell is further damaged, may become greatly swollen. Dyskeratosis is indicated by the precocious formation of cornifying granules (which is not specific) and the retention of observable structures, possibly mitochondria, within the cells showing advanced cornification. [ABSTRACT FROM AUTHOR] |
Plný text