| Autor: |
Motaghian, Shirin, Heroabadi, Arash, Khanesari, Keyvan Teymourei, Pestehei, Seyed Khalil, Marashi, Mojtaba, Yekta, Reza Atef |
| Zdroj: |
Archives of Neuroscience; Oct2023, Vol. 10 Issue 4, p1-5, 5p |
| Abstrakt: |
Background: Postoperative cognitive dysfunction (POCD) is a significant complication, especially prevalent among elderly individuals following major surgical procedures. Objectives: This study aims to compare the impact of isoflurane and propofol on the occurrence of POCD in patients undergoing elective laminectomy surgery under general anesthesia. Methods: This randomized, double-blind clinical trial took place at Shariati Hospital in Tehran. Patients scheduled for elective laminectomy between December 2020 and November 2021 were enrolled in the study and randomized into 2 groups. Patients in Group P received a Propofol infusion, while patients in Group I were administered isoflurane. Cognitive function assessments were conducted using the Mini-Mental State Examination (MMSE) at 3-time points: Twelve hours before surgery and 6 and 24 hours after surgery. Results: TheMMSEscores demonstrated a significant increase in the Propofol group compared to the Isoflurane group at the 6-hour and24-hour post-surgery time points. However, nosignificant differencewasobserved at baseline before surgery (P=0.04, P=0.005, and P = 0.2, respectively). Conclusions: These findings suggest that the use of propofol for general anesthesia may be a favorable choice for surgical procedures in elderly patients. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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