| Autor: |
Biswas, Subhamoy, Bora, Surjya Kumar, Arandhara, Pallav Jyoti, Saikia, Anil K. |
| Předmět: |
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| Zdroj: |
New Journal of Chemistry; 6/21/2024, Vol. 48 Issue 23, p10756-10761, 6p |
| Abstrakt: |
A TfOH-mediated, metal-free protocol for the synthesis of spiro-furan/pyran quinazolinones through a cascade hydroalkoxylation and intramolecular amide-cyclization reaction of alkynol ureas has been unveiled. This methodology facilitates the generation of highly functionalized spiro-heterocycles with remarkable yields and exclusive regioselectivity. Furthermore, the applicability of the strategy extends to the synthesis of spiro-pyrrolidine quinazolinones. Finally, post-synthetic modification incorporates bromide functionality into the synthesized spiro-heterocycle. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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