| Autor: |
ÇELİK GÖKSOY, Şeyda, TANIR, Yaşar, SOYLU, Nusret, BAKİ, Adile Merve, VURAL, Pervin, KARAYAĞMURLU, Ali |
| Předmět: |
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| Zdroj: |
Archives of Neuropsychiatry / Nöropsikiyatri Arşivi; Jun2024, Vol. 61 Issue 2, p141-147, 7p |
| Abstrakt: |
Introduction: There is a significant, but poorly understood, male preponderance in prevalence of autism spectrum disorder (ASD). The aim of this study was to examine the relationship between male preponderance in ASD and Inhibin B (InhB) and Anti-Müllerian hormone (AMH) levels and the 2D/4D finger ratio associated with fetal androgen exposure. Methods: 42 patients with ASD and 42 neurotypical controls between the ages of 5 and 10 were included. ASD diagnosis and severity were determined using K-SADS PL (Kiddie-SADS -- Present and Life Time) Version 2016 and the Childhood Autism Rating Scale (CARS). Serum InhB and AMH were measured. The 2D/4D finger length ratio was also calculated for hand anthropometric measurements. Results: Serum InhB levels were higher in children diagnosed with ASD compared to the neurotypical controls (p=0.003). Serum AMH levels were similar in both groups. Positive correlation was determined between AMH and CARS scores (r=0.315, p=0.05). 2D/4D finger ratios in the ASD group were significantly lower than in the control group (p<0.001). Conclusion: The study findings suggest that InhB, AMH, and fetal testosterone may be associated with male preponderance in ASD. More research is now required for a better understanding of this subject. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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