| Autor: |
Holmdahl, Idun, Lüning, Sofia, Wärnberg Gerdin, Sabina, Asarnoj, Anna, Hoyer, Angela, Filiou, Anastasia, Sjölander, Anders, James, Anna, Borres, Magnus P., Hedlin, Gunilla, van Hage, Marianne, Söderhäll, Cilla, Konradsen, Jon R. |
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| Zdroj: |
Acta Paediatrica; Jun2024, Vol. 113 Issue 6, p1376-1384, 9p |
| Abstrakt: |
Aim: This study explored whether early- life factors, such as rhinovirus- induced wheeze and allergic sensitisation, were related to asthma at 11 years of age. Methods: We focused on 107 children aged 6-48 months, who attended the paediatric emergency department at Astrid Lindgren's Children's Hospital in Stockholm, Sweden, with acute wheeze in 2008-2012. They also attended follow- up visits at 11 years of age and were compared with 46 age-matched healthy controls. Odds ratios (OR) with 95% confidence intervals (CI) were calculated with logistic regression. Results: We found that 62.6% of the acute wheeze cases had asthma at 11 years of age. Rhinoviruses at inclusion were the only common airway viruses associated with an increased asthma risk (OR 2.4, 95% CI 1.02-5.6). Other increased risks were parental heredity for asthma and/or allergies (adjusted OR 3.4, 95% CI 1.1-9.9) and allergic sensitisation at 2 years of age (adjusted OR 3.0, 95% CI 1.02-8.7). The highest prevalence of asthma was when children had both rhinovirus- induced wheeze at inclusion and allergic sensitisation at 7 years of age. Conclusion: Our findings highlight the importance of hereditary factors and allergic sensitisation on the development of asthma and suggest that rhinoviruses are associated with asthma development in predisposed children. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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