Salvia miltiorrhiza bunge extracts: a promising source for anti-atopic dermatitis activity.
| Autor: | Ryu, Da Hye, Cho, Jwa Yeong, Yu, Hyung-Seok, Kim, Jin-Woo, Kim, Jin-Chul, Son, Yang-Ju, Nho, Chu Won, Hamayun, Muhammad, Kim, Ho-Youn |
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| Předmět: |
THERAPEUTIC use of antioxidants
PHYTOTHERAPY ATOPIC dermatitis ANTI-inflammatory agents IN vitro studies HIGH performance liquid chromatography PEARSON correlation (Statistics) STATISTICAL significance RESEARCH funding PHYTOCHEMICALS DESCRIPTIVE statistics PLANT extracts REACTIVE oxygen species METABOLITES GENES MESSENGER RNA MEDICINAL plants ANTIOXIDANTS MASS spectrometry PHENOLS ANALYSIS of variance COMPARATIVE studies BIOLOGICAL assay DATA analysis software PHARMACODYNAMICS |
| Zdroj: | BMC Complementary Medicine & Therapies; 6/6/2024, Vol. 24 Issue 1, p1-14, 14p |
| Abstrakt: | Background: Atopic dermatitis (AD) is a chronic inflammatory condition characterized by the accumulation of reactive oxygen species and the expression of inflammatory factors. Regarding its anti-atopic activity, numerous traditional medicinal materials and secondary metabolic products play pivotal roles in modulating the associated mechanisms. Methods: This study aimed to utilize Salvia miltiorrhiza Bunge (SMB) as an anti-AD source. In-vitro activity assessments and qualitative and quantitative analyses using UPLC-TQ-MS/MS and HPLC-DAD were conducted in two cultivars ('Dasan' and 'Kosan'). Statistical analysis indicated that the profiles of their secondary metabolites contribute significantly to their pharmacological properties. Consequently, bio-guided fractionation was undertaken to figure out the distinct roles of the secondary metabolites present in SMB. Results: Comparative study of two cultivars indicated that 'Dasan', having higher salvianolic acid A and B, exhibited stronger antioxidant and anti-inflammatory activities. Meanwhile, 'Kosan', containing higher tanshinones, showed higher alleviating activities on anti-AD related genes in mRNA levels. Additionally, performed bio-guided fractionation re-confirmed that the hydrophilic compounds of SMB can prevent AD by inhibiting accumulation of ROS and suppressing inflammatory factors and the lipophilic components can directly inhibit AD. Conclusions: SMB was revealed as a good source for anti-AD activity. Several bioactive compounds were identified from the UPLC-TQ-MS/MS and different compounds content was linked to biological activities. Characterization of these compounds may be helpful to understand differential role of secondary metabolites from SMB on alleviation of AD. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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