| Abstrakt: |
Researchers from Comenius University in Bratislava, Slovakia have published a report on the role of Ca2+-dependent Cl- channels (CaCCs) in regulating vascular tone during aging. The study highlights the importance of identifying age-related alterations in vascular tone regulation for improving the diagnosis of cardiovascular diseases. The researchers explain the molecular and electrophysiological mechanisms of CaCCs activation in vascular smooth muscle cells and endothelium, as well as the age-dependent changes that affect the activation of CaCCs. The decline in CaCCs activation during aging involves a decrease in protein level, impairment of Ca2+ influx, and other alterations in vascular tone regulation. [Extracted from the article] |
