Researcher at University of the West of Scotland Zeroes in on Thiazoles (Sodium Metabisulfite Inhibits Acanthamoeba Trophozoite Growth through Thiamine Depletion).

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Zdroj: Genomics & Genetics Weekly; 6/14/2024, p1656-1656, 1p
Abstrakt: A recent study conducted at the University of the West of Scotland has found that sodium metabisulfite, a common ingredient in eye care solutions, can inhibit the growth of Acanthamoeba trophozoites, which cause a severe eye infection called Acanthamoeba keratitis. The researchers discovered that sodium metabisulfite depletes thiamine, a necessary nutrient for the growth of Acanthamoeba, and that the inhibitory effects can be reversed with thiamine supplementation. This study suggests that sodium metabisulfite could be a potential treatment for Acanthamoeba keratitis, and further research could explore other compounds that exploit the lack of thiamine biosynthesis in Acanthamoeba. [Extracted from the article]
Databáze: Complementary Index