| Autor: |
Shirolapov, I. V., Zakharov, A. V., Smirnova, D. A., Lyamin, A. V., Gayduk, A. J. |
| Zdroj: |
Neuroscience & Behavioral Physiology; Mar2024, Vol. 54 Issue 3, p398-403, 6p |
| Abstrakt: |
Selective and progressive neuronal death is a characteristic feature of the neurodegenerative process and leads to corresponding neuronal dysfunctions. Neurodegenerative diseases constitute a heterogeneous group of nosologies with different clinical presentations but similar molecular mechanisms of pathogenesis. They are based on the processes of abnormal protein aggregation, the formation of fibrillar insoluble structures, and their deposition as histopathological inclusions in nervous system tissues. Disruption of homeostatic functions regulating neuronal ion and energy metabolism, protein and nucleotide biosynthesis and degradation, chronic hypoxia, and penetration of toxic and inflammatory substances into the brain from the bloodstream not only cause age-related metabolic changes and disturbances in the sleep–waking cycle, but also contribute to the development of neurodegenerative processes. Animal studies have identified pathways for the perivascular clearance of solutes and specific tracers into the meningeal lymphatics. The glymphatic network facilitates the clearance of metabolites, including amyloid β and tau protein, from the parenchymal extracellular space of the brain. This review discusses the observations that the glymphatic system is more efficient during natural sleep and that the fluid dynamics through this pathway exhibit daily fluctuations and are under circadian control. The discussion addresses key aspects and scientific data from recent studies on the role of the glymphatic pathway and astroglial aquaporin type 4 as its main determinant in maintaining homeostatic fluid circulation in the brain in normal and pathological conditions, particularly in connection with the regulatory role of the sleep–waking cycle and during the development of neurodegenerative processes. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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