| Autor: |
Rubenstein, Emma, Henneton, Pierrick, Rivière, Sophie, Casanova, Marie-Laure, Broner, Jonathan, Arnaud, Erik, Oziol, Eric, Quintrec, Moglie Le, Moranne, Olivier, Jorgensen, Christian, Combe, Bernard, Bourdin, Arnaud, Fontaine, Christophe, Schiffmann, Aurélie, Fraison, Jean-Baptiste, Hallé, Olivier, Fraisse, Thibaut, Veysseyre, Frederic, Taieb, Guillaume, Aerts, Cécile |
| Předmět: |
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| Zdroj: |
Rheumatology; Jun2024, Vol. 63 Issue 6, p1552-1559, 8p |
| Abstrakt: |
Objectives This study aimed to estimate the prevalence of ANCA-associated vasculitis (AAV). That is, granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA) and eosinophilic granulomatosis with polyangiitis (EGPA), in Southern France in 2018, and evaluate differences among Europeans and non-Europeans. Methods This population-based, cross-sectional study used four sources (hospitals, community-based physicians, laboratories, National Health Insurance) to identify adults ≥15 years diagnosed with GPA, MPA or EGPA, living in Hérault and Gard in 2018. Cases were defined using the ACR/EULAR classification criteria, and if necessary, the European Medicines Agency algorithm. Prevalence estimates were standardised to the world population and capture-recapture analysis was used to assess the comprehensiveness of the estimation. The influence of geographical origin was evaluated. Results A total of 202 patients were selected, with 86 cases of GPA (42.6%), 85 cases of MPA (42.1%) and 31 cases of EGPA (15.3%). The standardised prevalence estimates per million inhabitants for 2018 were: 103 (95%CI 84–125) for AAV, 48 (95%CI 35–64) for GPA, 39 (95%CI 28–53) for MPA and 16 (95%CI 9–26) for EGPA, 36 (95%CI 25–50) for anti-PR3 positive AAV, 46 (95%CI 34–61) for anti-MPO positive AAV, and 16 (95%CI 9–26) for ANCA-negative AAV. The global estimation of comprehensiveness by capture-recapture analysis was 80.5%. The number of AAV cases was higher for non-European residents (P = 0.001), particularly for MPA (P < 0.0001). Conclusion We provide a new estimate of AAV prevalence in France and show a higher prevalence of MPA in non-European patients. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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