Study of the Pressing Process of N-Butyl-N-Methyl-1-Phenylpyrrolo-[1,2-a]Pyrazine-3-Carboxamide (GML-3) Tablets Using Mathematical Modeling Techniques.

Autor: Markeev, V. B., Tishkov, S. V., Blynskaya, E. V., Alekseev, K. V.
Předmět:
Zdroj: Pharmaceutical Chemistry Journal; Mar2024, Vol. 57 Issue 12, p1998-2003, 6p
Abstrakt: N-Butyl-N-methyl-1-phenylpyrrolo[1,2-a]pyrazine-3-carboxamide (GML-3) is an original molecule developed at the Research Zakusov Institute of Pharmacology. GML-3 has both anxiolytic and antidepressant activity, which makes the development of tablets based on it a promising task. Optimization of the pressing process is currently an urgent task of the pharmaceutical industry because this technological stage has a significant impact on the disintegration of tablets and the release of the active pharmaceutical ingredient. The Heckel and Kuenz–Leuenberger models were used to study the pressing process of GML-3 tablets. These models were compared to select the most reliable description of pressing GML-3 tablets from granules. Granules with polyvinylpyrrolidone (PVP) and hydroxypropylmethylcellulose (HPMC) as a binder were used. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
Externí odkaz: