| Autor: |
Shakirzyanova, G. S., Izotova, L. Yu., Kholbekov, O. Kh., Zhaloliddinov, F. Yu., Rakhmonova, G. G., Babaev, B. N. |
| Předmět: |
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| Zdroj: |
Pharmaceutical Chemistry Journal; Mar2024, Vol. 57 Issue 12, p1898-1902, 5p |
| Abstrakt: |
5,5′-(Disulfanediyl)bis[3-phenyl-1,3,4-thiadiazole-2(3H)-thione] was synthesized by oxidative condensation in the presence of chloride ions. The structure of the resulting compound was identified by an x-ray crystal structure analysis, for which the crystallographic data were obtained. The anti-inflammatory activity of the synthesized disulfide was studied for the first time in a carrageenan edema model. 5,5′-(Disulfanediyl)bis[3-phenyl-1,3,4-diazole-2(3H)-thione] was shown to have anti-inflammatory and antiexudative activity at doses of 10 and 20 mg/kg. Its effect was close to that of the drug Nimesil. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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