| Autor: |
Sbierski-Kind, Julia, Schlickeiser, Stephan, Feldmann, Svenja, Ober, Veronica, Grüner, Eva, Pleimelding, Claire, Gilberg, Leonard, Brand, Isabel, Weigl, Nikolas, Ahmed, Mohamed I. M., Ibarra, Gerardo, Ruzicka, Michael, Benesch, Christopher, Pernpruner, Anna, Valdinoci, Elisabeth, Hoelscher, Michael, Adorjan, Kristina, Stubbe, Hans Christian, Pritsch, Michael, Seybold, Ulrich |
| Předmět: |
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| Zdroj: |
Infection; Jun2024, Vol. 52 Issue 3, p1087-1097, 11p |
| Abstrakt: |
Background: Innate lymphoid cells (ILCs) are key organizers of tissue immune responses and regulate tissue development, repair, and pathology. Persistent clinical sequelae beyond 12 weeks following acute COVID-19 disease, named post-COVID syndrome (PCS), are increasingly recognized in convalescent individuals. ILCs have been associated with the severity of COVID-19 symptoms but their role in the development of PCS remains poorly defined. Methods and results: Here, we used multiparametric immune phenotyping, finding expanded circulating ILC precursors (ILCPs) and concurrent decreased group 2 innate lymphoid cells (ILC2s) in PCS patients compared to well-matched convalescent control groups at > 3 months after infection or healthy controls. Patients with PCS showed elevated expression of chemokines and cytokines associated with trafficking of immune cells (CCL19/MIP-3b, FLT3-ligand), endothelial inflammation and repair (CXCL1, EGF, RANTES, IL-1RA, PDGF-AA). Conclusion: These results define immunological parameters associated with PCS and might help find biomarkers and disease-relevant therapeutic strategies. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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