An Audit of Antibiotic Usage and Its Concordance with the Sensitivity Pattern Following Emergency Abdominal Surgery.

Autor:	Madan, Misha, Lekshmi, Satheesh, Gurushankari, Balakrishnan, Dhanajayan, Govindan, Mahalakshmy, Thulasingam, Sureshkumar, Sathasivam, Kate, Vikram
Předmět:	ANTIBIOTICS ABDOMINAL surgery AUDITING MEDICAL protocols CULTURAL awareness MICROBIAL sensitivity tests T-test (Statistics) DRUG resistance in microorganisms FISHER exact test DRUG administration EMERGENCY medical services TERTIARY care DESCRIPTIVE statistics CHI-squared test MANN Whitney U Test ANTI-infective agents LONGITUDINAL method ESCHERICHIA coli KLEBSIELLA infections ANALYSIS of variance METRONIDAZOLE ENTEROCOCCUS faecium SURGICAL site infections DATA analysis software MINOCYCLINE CEFTAZIDIME DRUG utilization CEFTRIAXONE TIME
Zdroj:	Indian Journal of Surgery; Apr2024, Vol. 86 Issue 2, p318-324, 7p
Abstrakt:	This study aims to audit the antibiotic usage and its concordance with the sensitivity pattern following emergency abdominal surgeries. This longitudinal study comprised a single group of patients above 18 years of age, who underwent emergency abdominal surgeries. The antibiotic administered preoperatively was noted. The sensitivity patterns of organisms isolated from intraoperative fluid or blood cultures were noted. The concordance between the antibiotics given and the culture sensitivity reports was analyzed. A total of 97 patients were included in the study. Among the 97 patients, 62 were included for analyzing antibiotic concordance after excluding the cases where cultures were not sent or if the antibiotic was stopped. The antibiotic usage was found to be concordant in 35/62 cases (56.40%) and discordant in 27/62 cases (43.54%). Out of the total discordant cultures, the first-line antibiotics were discordant in 62.9% (n = 17) and the second-line antibiotics were discordant in 37.04% (n = 10) cases. The maximum resistance among antibiotics was found against minocycline (80%), followed by ceftazidime (73.45%) and ciprofloxacin (73.45%). The most commonly isolated organism from the cultures was Escherichia coli, followed by Klebsiella pneumoniae. The concordance of antimicrobial usage was seen in 56% of cases. The most commonly isolated organisms isolated in the culture were Escherichia coli, followed by Klebsiella pneumoniae. The highest resistance was recorded against minocycline followed by cefotaxime and ciprofloxacin. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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