| Autor: |
Li, Chen-xi, Su, Ying, Wang, Zheng-ye, Liu, Hui, Gong, Zhong-cheng, Zhao, Hua-rong |
| Předmět: |
|
| Zdroj: |
Oral & Maxillofacial Surgery; Jun2024, Vol. 28 Issue 2, p739-752, 14p |
| Abstrakt: |
Objectives: The use of miR-21 expression remains vague in diagnosis of head and neck squamous cell carcinoma (HNSCC). This study aimed to systematically evaluate the diagnostic potential of the miR-21 expression in patients with HNSCCs through investigating and summarizing the results reported in the literature. Methods: Extant medical databases were examined for articles of clinical study assessing the miR-21 expression in HNSCC cases, published in the past 20 years. Bioinformatics research was also performed for finding miR-21 targets differentially expressed in HNSCC so as to present their biological behaviors. Results: Our meta-analysis comprised 11 studies including 622/450 cases in HNSCC/control group. Forest plots displayed miR-21 which possessed significantly good specificity (0.76, p < 0.001) and sensitivity (0.80, p < 0.001). Diagnostic odds ratio was 2.46 (95% CI 1.87–3.24). Positive and negative likelihood ratio was 3.40 (95% CI 1.94–5.97) and 0.26 (95% CI 0.18–0.38), respectively. Area under the receiver operating characteristic curve was 0.85. Conclusion: This study is the highest level of evidence presently available in diagnosing HNSCC. This PRISMA meta-analysis indicated that the pooled results were robust, confirming the oncogenic potential of miR-21 that could be used successfully as a screening biomarker in HNSCC patients. Specifically, the overexpression of miR-21 in these patients presents a worse survival outcome. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
Full text from SpringerLink