New Antibiotics Study Results Reported from University of Texas Southwestern Medical Center (Susceptible Bacteria Can Survive Antibiotic Treatment In the Mammalian Gastrointestinal Tract Without Evolving Resistance).

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Zdroj: Gastroenterology Week; 6/7/2024, p1205-1205, 1p
Abstrakt: A recent study conducted by the University of Texas Southwestern Medical Center has found that certain bacteria in the mammalian gastrointestinal tract can survive antibiotic treatment without developing resistance. The researchers used genetically barcoded Escherichia coli to colonize germ-free mice and administered the antibiotic cefepime to mimic human antibiotic dynamics. They discovered that some E. coli isolates acquired mutations that increased their invasion and survival within human intestinal cells, allowing them to evade antibiotic treatment. This research sheds light on a mechanism that enables gastrointestinal bacteria to resist antibiotics. [Extracted from the article]
Databáze: Complementary Index