| Autor: |
Sondari, Dewi, Hanifah, Arzqa S., Amanda, Putri, Hermanto, Sandra, Septevani, Athanasia Amanda, Ningrum, Riska Surya, Suwarda, Rosniyati, Hermiati, Euis, Ermawar, Riksfardini Annisa, Pramasari, Dwi Ajias |
| Zdroj: |
Waste & Biomass Valorization; Jun2024, Vol. 15 Issue 6, p3739-3748, 10p |
| Abstrakt: |
This research produces dialdehyde cellulose from Cellulose of sugarcane waste leaves (STL) and then combined it with chitosan to make a hydrogel biocomposite for drug delivery matrices. Cellulose from STL produced by delignification of STL using two different methods namely autoclave-alkali and microwave/autoclave-alkali which produced α-cellulose ranging from 43 to 66%. The hydrogel was prepared with dialdehyde cellulose and chitosan ration (3:1 w/w) and crosslinked with Sodium trimetaphosphate (STMP). The functional groups of dialdehyde cellulose and hydrogel were analyzed using FTIR, and the surface morphology and thermal stability of hydrogel were measured by SEM and TGA respectively. The Swelling capacity of the hydrogel showed that the hydrogel sample had swelling values ranging from 120 to 450%. The results of hydrogel activity as a drug delivery matrice showed that the drug loading around 21 mg/g with encapsulation efficiency 55.23% in HCL and 70.63% in PBS medium. The hydrogel showed a drug release range of 8.24–58.79% on PBS medium pH 7.4 and 0.1 M HCl medium in the range of 7.32–90.57% after 5 h of drug release. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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