| Autor: |
Shima, Takeru, Kawabata-Iwakawa, Reika, Onishi, Hayate, Yoshikawa, Tomonori, Yoshii, Keisuke, Yoshikawa, Yuika |
| Předmět: |
|
| Zdroj: |
Sport Sciences for Health; Jun2024, Vol. 20 Issue 2, p387-393, 7p |
| Abstrakt: |
Purpose: Exercise positively impacts social abilities like empathy, which is indispensable for sustaining relationships with others. Regular exercise at light intensity enhances empathic behavior; nonetheless, its biomarkers remain unknown. Here, we evaluated the effects of light-intensity exercise, which enhances helping behavior, on circulating miRNA profile in mice. Methods: Eight-week-old male C57BL/6 mice were subjected to exercise at light intensity (7.0 m/min, 30 min/day, 5 days/week) for four weeks and a helping behavior test. The plasma was subsequently collected to analyze miRNA expressions using next-generation sequencing. Results: We found that four weeks of light-intensity exercise significantly increased 11 miRNAs in the plasma of mice. This exercise regimen also significantly reduced 29 miRNAs in the plasma of mice. Seven out of 11 upregulated miRNAs and nine of 29 downregulated miRNAs showed significant correlations with helping behavior in mice; the miRNAs related to neuronal growth were also included, such as miR-29a-3p and miR-142b. Conclusion: These results imply that miRNAs are applicable as liquid biomarkers for reflecting the effects of light-intensity exercise on empathy; it might also be developed as a possible indicator for treating empathy. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
Full text from SpringerLink