Psilocybin does not induce the vulnerability marker HSP70 in neurons susceptible to Olney's lesions.

Autor:	Iorgu, Ana-Maria, Vasilescu, Andrei-Nicolae, Pfeiffer, Natascha, Spanagel, Rainer, Mallien, Anne Stephanie, Inta, Dragos, Gass, Peter
Předmět:	PSILOCYBIN METHYL aspartate receptors CINGULATE cortex HEAT shock proteins NEURONS SEROTONIN syndrome
Zdroj:	European Archives of Psychiatry & Clinical Neuroscience; Jun2024, Vol. 274 Issue 4, p1013-1019, 7p
Abstrakt:	S-ketamine, a N-methyl-D-aspartate receptor (NMDAR) antagonist, and psilocybin, a 5-hydroxy-tryptamine (serotonin) 2A receptor (5-HT2AR) agonist, are reported as effective rapid-acting antidepressants. Both compounds increase glutamate signalling and evoke cortical hyperexcitation. S-ketamine induces neurotoxicity especially in the retrosplenial cortex (Olney's lesions). Whether psilocybin produces similar neurotoxic effects has so far not been investigated. We performed an immunohistochemical whole-brain mapping for heat shock protein 70 (HSP70) in rats treated with psilocybin, S-ketamine, and MK-801. In contrast to S-ketamine- and MK-801-treated animals, we did not detect any HSP70-positive neurons in retrosplenial cortex of rats treated with psilocybin. Our results suggest that psilocybin might be safer for clinical use compared to S-ketamine regarding neuronal damage. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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