| Autor: |
Novak, Frederik, Bajwa, Hamza Mahmood, Østergaard, Kamilla, Berg, Jonas Munksgaard, Madsen, Jonna Skov, Olsen, Dorte Aalund, Urbonaviciute, Inga, Illes, Zsolt, Stilund, Morten Leif, Romme Christensen, Jeppe, Bramow, Stephan, Sellebjerg, Finn, Sejbaek, Tobias |
| Předmět: |
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| Zdroj: |
Multiple Sclerosis Journal; Jun2024, Vol. 30 Issue 7, p847-856, 10p |
| Abstrakt: |
Background: This study investigates clinical and biomarker differences between standard interval dosing (SID) and extended interval dosing (EID) of ocrelizumab therapy in multiple sclerosis (MS). Methods: This is a prospective, double-arm, open-label, multi-center study in Denmark. Participants diagnosed with MS on ocrelizumab therapy >12 months were included (n = 184). Clinical, radiological, and blood-based biomarker outcomes were evaluated. MRI disease activity, relapses, worsening of neurostatus, and No Evidence of Disease Activity-3 (NEDA-3) were used as a combined endpoint. Results: Out of 184 participants, 107 participants received EID (58.2%), whereas 77 participants received SID (41.8%). The average extension was 9 weeks with a maximum of 78 weeks. When comparing EID to SID, we found higher levels of B-cells, lower serum concentrations of ocrelizumab, and similar levels of age-adjusted NFL and GFAP in the two groups. No difference in NEDA-3 between EID and SID was demonstrated (hazard ratio: 1.174, p = 0.69). Higher levels of NFL were identified in participants with disease activity. Body mass index correlated with levels of ocrelizumab and B-cells. Conclusion: Extending one treatment interval of ocrelizumab on average 9 weeks and up to 78 weeks did not result in clinical, radiological, or biomarker evidence of worsening compared with SID. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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