A connection between phosphatidylinositol 5-phosphate and the Hippo pathway to prevent epithelial-mesenchymal transition in cancer.

Autor:	Hirsch, Emilio, Fantastico, Emanuele, Prever, Lorenzo, Gulluni, Federico
Předmět:	HIPPO signaling pathway EPITHELIAL-mesenchymal transition YAP signaling proteins METASTASIS
Zdroj:	Science Signaling; 5/28/2024, Vol. 17 Issue 838, p1-2, 2p
Abstrakt:	The Hippo pathway blocks epithelial-mesenchymal transition and metastasis in cancer mediated by the transcriptional coactivator YAP. In this issue of Science Signaling, Palamiuc et al. demonstrate that phosphatidylinositol 5-phosphate (PI5P) enhances Hippo pathway activation and that simultaneously the Hippo pathway initiates a positive feedback loop by inhibiting the conversion of PI5P into PIP2. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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