Topographical distribution and prevalence of basal duct–like recess sign in a cohort of Papillary Craniopharyngioma—novel findings and implications.

Autor:	Malik, Prateek, Chen, Yingming Amy, Mathew, Benjamin Barsouma, Munoz, David G., Selvi, Bernice Thamarai, Vanjare, Harshad Arvind, Jasper, Anitha, Mannam, Pavithra, Bharatha, Aditya, Mathur, Shobhit
Předmět:	PREDICTIVE tests FISHER exact test BLOOD vessels COMPUTED tomography MAGNETIC resonance imaging RETROSPECTIVE studies CANCER patients DISEASE prevalence DESCRIPTIVE statistics CHI-squared test CRANIOPHARYNGIOMA RESEARCH DATA analysis software SENSITIVITY & specificity (Statistics)
Zdroj:	Neuroradiology; Jun2024, Vol. 66 Issue 6, p947-953, 7p
Abstrakt:	Purpose: Basal duct-like recess (DR) sign serves as a specific marker of papillary craniopharyngiomas (PCPs) of the strictly third-ventricular (3 V) topography. Origins of this sign are poorly understood with limited validation in external cohorts. Methods: In this retrospective study, MRIs of pathologically proven PCPs were reviewed and evaluated for tumor topography, DR sign prevalence, and morphological subtypes. Results: Twenty-three cases with 24 MRIs satisfied our inclusion criteria. Median age was 44.5 years with a predominant male distribution (M/F ratio 4.7:1). Overall, strictly 3 V was the commonest tumor topography (8/24, 33.3%), and tumors were most commonly solid-cystic (10/24, 41.7%). The prevalence of DR sign was 21.7% (5/23 cases), all with strictly 3 V topography and with a predominantly solid consistency. The sensitivity, specificity and positive and negative predictive value of the DR sign for strict 3 V topography was 62.5%, 100%, 100% and 84.2% respectively. New pertinent findings associated with the DR sign were observed in our cohort. This included development of the cleft-like variant of DR sign after a 9-year follow-up initially absent at baseline imaging. Additionally, cystic dilatation of the basal tumor cleft at the pituitary stalk-tumor junction and presence of a vascular structure overlapping the DR sign were noted. Relevant mechanisms, hypotheses, and implications were explored. Conclusion: We confirm the DR sign as a highly specific marker of the strictly 3 V topography in PCPs. While embryological and molecular factors remain pertinent in understanding origins of the DR sign, non-embryological mechanisms may play a role in development of the cleft-like variant. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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