Myelodysplastic Syndrome: Clinical Characteristics and Significance of Preclinically Detecting Biallelic Mutations in the TET2 Gene.

Autor:	Danishevich, Anastasiia, Chegodar, Anzhelika, Bodunova, Natalia, Konovalov, Fedor, Nefedova, Maria, Kremneva, Natalya, Kurbanov, Nizhat, Bilyalov, Airat, Nikolaev, Sergey, Khatkov, Igor, Dudina, Galina
Předmět:	MYELODYSPLASTIC syndromes ACUTE myeloid leukemia GENETIC mutation HEMATOPOIETIC stem cells CYTOPENIA
Zdroj:	Life (2075-1729); May2024, Vol. 14 Issue 5, p637, 12p
Abstrakt:	Myelodysplastic syndrome (MDS) is a clonal disease derived from hematopoietic stem cells, characterized by ineffective hematopoiesis (resulting in peripheral blood cytopenia) and an increased risk of transformation into acute myeloid leukemia. MDS is caused by a complex combination of genetic mutations resulting in a heterogeneous genotype. Genetic studies have identified a set of aberrations that play a central role in the pathogenesis of MDS. In this article, we present a clinical case of MDS transformation into acute myeloid leukemia in the context of two cell lines exhibiting morphological, immunophenotypic, and dysmyelopoiesis markers and the presence of two heterozygous mutations in the TET2 gene. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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