| Autor: |
Huang, Jie, Zhang, Shi‐Ling, Zhang, Chao, Huang, Weiye, Zhang, Zhenhua, Chen, Yu‐Qing, Su, Jun‐Wei, Yan, Hong‐Hong, Chen, Hua‐Jun, Yang, Jin‐Ji, Wang, Junjian, Wu, Yi‐Long |
| Předmět: |
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| Zdroj: |
Clinical & Translational Medicine; May2024, Vol. 14 Issue 5, p1-7, 7p |
| Abstrakt: |
This article discusses a study that examines the genetic and molecular characteristics of lung cancer patients who have transformed from one type of lung cancer to another. The study identifies two distinct subtypes based on the RB1 gene status of the patients. The findings suggest that RB1 and SMAD4 alterations are important factors in this transformation, and patients with RB1 mutations tend to have a longer time before the transformation occurs. The article highlights the importance of understanding the heterogeneity within this patient population in order to develop new treatments and improve outcomes. Additionally, the study develops a predictive model to assess the risk of transformation in patients with specific gene mutations. Overall, this research provides valuable insights into the biology of transformed lung cancer and potential targets for therapy. [Extracted from the article] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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