Comparison of the Effect of Kombucha and Vitamin C on Coronary Arteries in Rabbits Exposed to Lead and High-cholesterol Diet.
| Autor: | Rajabzadeh, Asghar, Vahedi, Parviz, Vahedi, Hadi |
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| Předmět: |
KOMBUCHA tea
VITAMIN C DATA analysis STATISTICAL significance RESEARCH funding LIPIDS ENDOTHELIUM ATHEROSCLEROSIS DESCRIPTIVE statistics CORONARY arteries AORTA PLANT extracts ANIMAL experimentation ENDOTHELIAL cells ONE-way analysis of variance STATISTICS FREE radicals MICROSCOPY STAINS & staining (Microscopy) DATA analysis software LEAD DIETARY cholesterol RABBITS |
| Zdroj: | Shiraz E Medical Journal; Mar2024, Vol. 25 Issue 3, p1-9, 9p |
| Abstrakt: | Background: Vitamin C and kombucha contain a high amount of glucuronic acid that can prevent cholesterol accumulation and convert cholesterol to amore water-soluble compound. Objectives: The aimof this studywas to compare the effects of kombucha and vitamin C on the coronary arteries and aorta ofmale rabbits exposed to lead acetate fed with a high-cholesterol diet. Methods: Fortymale rabbits were divided randomly into four groups of 10 animals. Group 1 served as a control group. Rabbits in group 2 received water containing 547 ppmof lead acetate and a high-cholesterol diet (1%). Group 3 received water containing 547 ppmlead acetate and a high-cholesterol diet (1%) in combination with ascorbic acid (500mg/kg), and group 4 rabbits were treated with water containing 547 ppmlead acetate and kombucha extract (10ml/kg) for 40 days orally on a high-cholesterol diet (1%). Results: The results showed that in groups 3 and 4, no significant atherosclerotic plaques could be detected in coronary arteries, compared to the control animals. However, large atherosclerotic plaques were observed in the aortas of those treated only with kombucha. The datawere analyzed using analysis of variance (ANOVA) statisticalmethods. Themean ± standard error of themean (SEM) triglyceride (TG) serumlevels in groups 1, 2, 3, and 4 were 122.70 ± 66.77, 280.60 ± 88.66, 120.10 ± 8.33, and 107.86 ± 8.61mg/dL, respectively. Themean ± SEM TG serumlevels in groups 1, 2, 3, and 4 were 67.80 ± 10.33, 67.90 ± 10.10, 60.80 ± 8.16, and 58.71 ± 4.78 mg/dL, respectively. The mean ± SEM TG serum levels in groups 1, 2, 3, and 4 were 194.50 ± 6.58, 182.60 ± 13.75, 178.30 ± 18.01, and 166.00 ± 7.65mg/dL, respectively. P-values for low-density lipoprotein (LDL), high-density lipoprotein (HDL), and TG were reported as P < 0.001, P = 0.077, and P < 0.001, respectively. Conclusions: It could be concluded that kombucha, unlike vitamin C, cannot prevent the formation of large plaques in the aorta, although it seems that it can prevent atherosclerotic lesions in coronary arteries. Therefore, further studies are required to evaluate the long-termuse of kombucha to assess whether higher doses are beneficial in preventing atherosclerotic events or not. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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