| Abstrakt: |
Abstract—According to modern concepts, biochemical cascades activated in response to stress also contribute to cognitive functions, such as learning and memory formation. Considering a conditioned reflex as an adaptation to the external environment, one can assume its occurrence as a reaction to external challenges, which, when reinforced, contribute to the formation of a conditioned connection, and in the absence, cause the development of a stress response. The metabolic activity of the body is inextricably linked with circadian rhythms, which determine the daily fluctuations in light, temperature, oxygen content, and magnetic field. The integration of these timers is carried out by a protein of the cryptochrome family (CRY), which functions as a blue light receptor and is known as a repressor of the main circadian transcription complex CLOCK/BMAL1. In order to develop methods for non-invasive correction of pathologies of the nervous system on a model object of genetics, mutant strains of Drosophila are used to study the relationship between adaptive mechanisms of the formation of a conditioned connection and the development of a stress response to a weakening of the magnetic field, hypoxia and temperature changes. The data are discussed in light of the role of the CRY/CLOCK/BMAL1 system as a link in magnetoreception, hypoxia, circadian rhythm regulation, cognitive functions, and DNA double-strand breaks in nerve ganglia (an indicator of the physiological activity of neurons) [ABSTRACT FROM AUTHOR] |
Full text from SpringerLink