| Autor: |
Zhao, Shukang, Li, Lianbo, Komohara, Yoshihiro, Matsubara, Eri, Shinchi, Yusuke, Adawy, Ahmad, Yano, Hiromu, Pan, Cheng, Fujiwara, Yukio, Ikeda, Koei, Suzu, Shinya, Hibi, Taizo, Suzuki, Makoto |
| Předmět: |
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| Zdroj: |
Medical Molecular Morphology; Jun2024, Vol. 57 Issue 2, p91-100, 10p |
| Abstrakt: |
Interleukin 32 (IL-32) is a proinflammatory cytokine secreted from several kinds of cancer cells. In the present study, we investigated the significance of IL-32 in lung adenocarcinoma by immunohistochemistry and bioinformatics analysis. IL-32 was positive in cancer cells of 21 cases (9.2%) of total 228 cases. Increased IL-32 gene expression was linked to worse clinical course in TCGA analysis, however, IL-32 expression in immunohistochemistry was not associated to clinical course in our cohort. It was also found that high IL-32 expression was seen in cases with increased lymphocyte infiltration. In vitro studies indicated that IFN-γ induced gene expression of IL-32 and PD1-ligands in lung adenocarcinoma cell lines. IL-32, especially IL-32β, also induced overexpression of PD1-ligands in human monocyte-derived macrophages. Additionally, Cancer-cell-derived IL-32 was elevated by stimulation with anticancer agents. In conclusion, IL-32 potentially induced by inflammatory conditions and anticancer therapy and contribute to immune escape of cancer cells via development the immunosuppressive microenvironment. IL-32 might be a target molecule for anti-cancer therapy. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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