| Autor: |
Silverberg, Jonathan I., Patel, Nisha, Warshaw, Erin M., DeKoven, Joel G., Belsito, Donald V., Atwater, Amber R., Taylor, James S., Sasseville, Denis, Reeder, Margo J., Houle, Marie-Claude, DeLeo, Vincent A., Maibach, Howard I., Fowler Jr, Joseph F., Zug, Kathryn A., Pratt, Melanie D., JiaDe Yu, Mowad, Christen M., Botto, Nina C., Adler, Brandon L. |
| Zdroj: |
Dermatitis (Mary Ann Liebert, Inc.); Mar/Apr2024, Vol. 35 Issue 2, p152-159, 8p |
| Abstrakt: |
Background: Allergic contact dermatitis is frequently caused by metals, including multiple metals simultaneously. Objectives: To assess characteristics and associations of positive and clinically relevant patch test (PT) reactions with solitary and concurrent metal sensitization. Methods: A retrospective analysis of PT results for nickel, cobalt, and/or chromium from the North American Contact Dermatitis Group between 2001 and 2018 (n = 43,522). Results: 18.0% had a positive/allergic reaction to nickel sulfate hexahydrate, 7.3% to cobalt chloride hexahydrate, and 3.0% to potassium dichromate. 87.9% patients had a currently relevant reaction to 0, 9.4% to 1, and 2.7% to multiple metals tested. Patients with 1 versus no currently relevant reactions to metal were more likely to have a primary dermatitis site of trunk, feet, and ears; patients with currently relevant reactions to multiple metals had more dermatitis affecting the trunk and ears. Metal sources varied by co-reacting metal, especially for patients with cobalt and chromium allergy. Jewelry was the most commonly identified source of nickel and cobalt for both solitary and concurrent metal allergy. Conclusions: Sensitization to multiple metals occurred in 6% of patients. Allergen sources varied between patients with sensitivity to 1 metal versus those who had concurrent sensitivity to cobalt and/or chromium. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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