| Autor: |
Atla, Bhagyalakshmi, Sudhakar, Peddireddi Venkata, Karri, Satyasri, Manda, Vijayasekhar, Vella, Varaprasad, Botta, Venkata Satya Kartheek |
| Předmět: |
|
| Zdroj: |
Journal of Dr. NTR University of Health Sciences; Apr-Jun2023, Vol. 12 Issue 2, p126-134, 9p |
| Abstrakt: |
Background: Mucormycosis is a fungal infection with an aggressive clinical course, especially in high-risk patients with co-morbidities. During the second wave of COVID-19, there was an exponential increase in mucormycosis infection. Aim: This study aimed to determine the clinicohistopathological profile of post-COVID-19 mucormycosis. Settings and Design: Hospital-based observational cross-sectional study for 2 months. Materials and Methods: Post-COVID-19 mucormycosis patients who were admitted to the hospital and underwent surgeries were included in the study. The surgical samples were grossly examined followed by tissue processing and staining with hematoxylin and eosin (H and E), special stains with periodic acid Schiff (PAS) were performed followed by microscopic examination. Results: The present study included 117 patients with post-COVID-19 mucormycosis. The mean age group in the study was 48 years with male preponderance (77.78%). The common clinical presentations of mucormycosis in the present study were facial swelling and headache (43.59%), ocular swelling (31.62%), and facial pain (30.76%). Corticosteroids were used in 67.52% of patients during COVID-19 treatment. In all, 89.74% of the total patients were diabetics. Blood counts revealed neutrophilic leukocytosis in 49.57% of patients. The maxillary sinus was the most commonly involved anatomical site (90.54%). On histopathological examination, pyogranulomatous inflammation was the most frequently observed type of inflammatory reaction in the surgical specimens. Coagulative necrosis was seen in 81.2%, thrombosis in 61.54%, angioinvasion in 37.6%, and perineural invasion seen in 12.82% of the patients. Statistical Analysis: Data were analyzed using Microsoft Excel, 2010. Conclusion: Thrombosis seems to be the consistent finding leading to coagulative necrosis. Angioinvasion is a significant finding in the pathology of mucormycosis. Identifying co-morbidities and risk factors, prompt diagnosis and treatment are imperative for the successful management of this deadly fungal infection. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
