| Autor: |
Khare, Arvind, Kumari, Suman, Thada, Beena, Singh, Maina, Mathur, Veena |
| Předmět: |
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| Zdroj: |
Journal of Dr. NTR University of Health Sciences; Jan-Mar2023, Vol. 12 Issue 1, p46-53, 8p |
| Abstrakt: |
and Aims: Epidural anaesthesia using local anaesthetic agent with or without adjuvant is an effective technique for providing both anaesthesia and postoperative analgesia. This study aimed to compare the clinical efficacy of dexmedetomidine and nalbuphine as an adjuvant with 0.5% ropivacaine under epidural anaesthesia in terms of duration of analgesia as a primary objective and onset and duration of sensory and motor blockade, VAS score, sedation score, haemodynamic changes and adverse effects as secondary objectives. Methods: This prospective, randomized, double blind study conducted on total of 100 patients belonging to ASA physical status I and II undergoing infraumbilical surgeries was randomly allocated into 2 groups--Group D (n = 50) received ropivacaine 0.5%, 18 ml and 0.75 µg/kg dexmedetomidine and Group N (n = 50) received ropivacaine 0.5%, 18 ml and 200 µg/kg nalbuphine in epidural anaesthesia. Results: The mean time for onset of sensory block was statistically faster in Group D (11.94 ± 1.66 min.) as compared to Group N (14.24 ± 2.14 min) (P < 0.0001). The duration of analgesia was statistically longer in Group D (353.86 ± 28.36 min.) as compared to Group N (295.28 ± 22.43 min) (P < 0.001). The mean time to achieve maximum level, two-segment regression of sensory block, onset of motor block and time to achieve maximum bromage score were comparable in both groups. Complete reversal of sensory and motor blockade was faster in Group N as compared to Group D. Hemodynamic parameters, VAS score and ramsay sedation score were comparable in both groups. Conclusion: Dexmedetomidine is a better adjuvant to ropivacaine for epidural anaesthesia when compared with nalbuphine as it provides earlier onset and prolonged duration of sensory block and postoperative analgesia with stable vitals and minimal side effects. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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