| Autor: |
Meravanige, Girish, Ranjitha B., Goudanavar, Prakash, Koteswara Rao, G. S. N., Devi, B. Nirmala, Naveen, N. Raghavendra, Asif, Afzal Haq, Nagaraja, Sree Harsha, Islam, Mohammed Monirul, Pavagada Sreenivasalu, Pavan Kumar, Telsang, Mallikarjun, Duddi Sreehari, Krishna Swaroop |
| Předmět: |
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| Zdroj: |
Indian Journal of Pharmaceutical Education & Research; Jan-Mar2024, Vol. 58 Issue 1, p131-138, 8p |
| Abstrakt: |
Background: The topical administration of antifungal drugs by Solid Lipid Nanoparticles (SLNs) has enormous potential. This study aimed to develop a topical 5-flucytosine-loaded SLNs gel to improve the efficacy of the well-known antifungal drug in the treatment of wound healing. Materials and Methods: In order to create 5-flucytosine SLNs, a five-level, two-factor Central-composite design was used. Stearic acid and Poloxamer 407 concentrations of surfactants were chosen as independent factors, and particle size and %Entrapment Efficiency (%EE) were chosen as dependent variables. The produced 5-Flucytosine-SLNs were examined using SEM analysis, zeta potential, polydispersity index, and particle size measurements. Additionally, Carbopol 934 was used to incorporate the improved 5-Flucytosine-SLN formula into gel. Results: The outcomes demonstrated that 5-Flucytosine-SLNs had colloidal sizes with an essentially spherical shape and no aggregation. 5-Flucytosine-SLNs were discovered to have a particle size of 720.4 nm and an Entrapment Efficiency (EE) of 90.28%. The in vitro release, among other assessment criteria, was evaluated for the improved SLN gels. Conclusion: The study's conclusions imply that the topical gels made with 5-Flucytosine-loaded SLNs must be effective in the management of wound healing. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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