| Abstrakt: |
A recent study conducted by researchers from Huazhong University of Science and Technology in Wuhan, China, explores the potential of using radiation-based immunogenic vaccines combined with a macrophage "checkpoint inhibitor" to boost the immune response against metastatic colon cancers. The researchers found that X-ray-induced dying tumor cells have highly immunogenic tumor-associated antigens and self-generated dsDNA, making them promising candidates for cancer vaccines. However, the X-ray induction process can lead to the excessive exposure of phosphatidylserine, which binds to the MerTK receptor on macrophages and promotes immune silence in the tumor microenvironment. To address this, the researchers developed a novel strategy that incorporates a macrophage MerTK "checkpoint inhibitor" to block the immunosuppressive effects of macrophages. This combination approach was found to promote the maturation of dendritic cells and repolarization of macrophages, leading to enhanced adaptive and innate immunity. The study suggests that this innovative approach could provide valuable insights for the development of effective cancer vaccines and immunotherapies targeting colon cancer. [Extracted from the article] |
