| Autor: |
Wu, Hui-Qian, Qi, Yu-Ting, Guo, Bing-Yi, Zhao, Yi, Zhang, Xin-Wei, Huang, Wei-Hua |
| Předmět: |
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| Zdroj: |
Chemical Communications; 5/25/2024, Vol. 60 Issue 42, p5546-5549, 4p |
| Abstrakt: |
Airborne nanoplastics can enter alveolar cells and trigger intracellular oxidative stress primarily. Herein, taking advantage of the high electrochemical resolution of SiC@Pt nanoelectrodes, we achieved the quantitative discrimination of the major ROS/RNS within A549 cells, disclosed the sources of their precursors, and observed that the NO (RNS precursor) level significantly increased, whereas O2˙− (ROS precursor) remained relatively stable during the nanoplastics exposure. This establishes that iNOS or mitochondrion-targeted treatment may be a preventive or therapeutic strategy for nanoplastic-induced lung injury. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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