| Autor: |
KŐRÖSI, Dénes, VOROBCSUK, András, FAJTAI, Dániel, TÁTRAI, Ottó, BODOR, Emőke, GARAMVÖLGYI, Rita |
| Předmět: |
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| Zdroj: |
Acta Agraria Kaposváriensis; 2023, Vol. 27 Issue 1/2, p77-85, 9p |
| Abstrakt: |
Pigs have played a significant role in biological and medical research for many years. In the case of non-rodent models, pigs are the primary choices as experimental animals in the cardiovascular studies. Accumulating data indicate that the closed-chest coronary balloon-occlusion technique is one of the most successful method for creating ischemic heart failure (HF). However, consistent and thoroughly characterized large animal models of HF are a critical translational tool for drug development and toxicology. The knowledge of the different catheterization protocols is crucial to ensure a suitable animal model which can serve as a human-related preclinical validation process. Therefore it is essential to follow an optimized and standardized experimental protocol on a homogenous animal population, which help to obtain reliable and useful data for the translational large animal research programs. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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