| Autor: |
Qingfeng Yang, Wei Huang, Jozwik, Catherine, Yong Lin, Glasman, Mirta, Caohuy, Hung, Srivastava, Meera, Esposito, Dominic, Gillette, William, Hartley, James, Pollard, Harvey B. |
| Předmět: |
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| Zdroj: |
Proceedings of the National Academy of Sciences of the United States of America; 7/5/2005, Vol. 102 Issue 27, p9631-9636, 6p |
| Abstrakt: |
Digitoxin and structurally related cardiac glycoside drugs potently block activation of the TNF-α/NF-κB signaling pathway. We have hypothesized that the mechanism might be discovered by searching systematically for selective inhibitory action through the entire pathway. We report that the common action of these drugs is to block the TNF-α-dependent binding of TNF receptor 1 to TNF receptor-associated death domain. This drug action can be observed with native cells, such as HeLa, and reconstituted systems prepared in HEK293 cells. All other antiinflammatory effects of digitoxin on NF-κB and c-Jun N-terminal kinase pathways appear to follow from the blockade of this initial upstream signaling event. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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