| Autor: |
Morii, Yuma, Watanabe, Taito, Saga, Yutaka, Kambe, Tetsuya, Kondo, Mio, Masaoka, Shigeyuki |
| Předmět: |
|
| Zdroj: |
ChemElectroChem; 5/17/2024, Vol. 11 Issue 10, p1-7, 7p |
| Abstrakt: |
In this study, we developed a novel electrochemical protocol that enables the functionalization of inherently inert C(sp3)−H bonds. In this protocol, one‐electron oxidation of acetic acid was used to successfully generate methyl radical, which cleaves the benzylic C(sp3)−H bonds of the substrates via a hydrogen atom transfer (HAT) process, and further reaction with the formed species yields the targeted C(sp3)−H functionalized products. To the best of our knowledge, this is the first example of the use of acetic acid in a HAT process. Notably the reaction has environment‐friendly and fine atom economy nature: the reaction is driven by the electrochemical conditions in the absence of expensive or hazardous reagents, producing only gaseous small molecules, hydrogen, carbon dioxide, and methane, as side products. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
Plný text