A new 3,4-seco-isopimarane and three new isopimarane diterpenoids from Kaempferia champasakensis collected from Vietnam and their cytotoxic activities.

Autor: Do, Kiep Minh, Hoshino, Shotaro, Kodama, Takeshi, Nguyen, Hien Minh, Van Le, Son, Ikumi, Naotaka, Onaka, Hiroyasu, Morita, Hiroyuki
Zdroj: Journal of Natural Medicines; Jun2024, Vol. 78 Issue 3, p537-546, 10p
Abstrakt: A phytochemical investigation of Kaempferia champasakensis rhizomes led to the isolation of a new 3,4-seco-isopimarane diterpene, kaempferiol A (1), and three new isopimarane diterpenes, kaempferiols B–D (2–4), together with six known isopimarane diterpenes (5–10). The structures of 1–4 were elucidated by extensive spectroscopic analyses, including HR-ESI–MS, UV, IR, and 1D and 2D NMR. The absolute configurations of 1, 3, and 4 were determined by ECD calculations, while that of 2 was established using the modified Mosher method. All isolated compounds were tested for cytotoxicity against three human cancer cell lines, lung cancer (A549), cervical cancer (HeLa), and breast cancer (MCF-7). Among them, 6 and 7 showed moderate cytotoxic activities against the three tested cell lines, with IC50 values ranging from 38.04 to 27.77 μM, respectively. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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