| Abstrakt: |
Researchers at the University of Missouri have developed a method to improve the success of pancreatic islet transplantation by mitigating the instant blood-mediated inflammatory reaction (IBMIR) that often destroys the transplanted islets. The researchers engineered the islets to display two proteins, thrombomodulin and CD47, on their surface. This combinatorial approach reduced the destruction of the islets by IBMIR, leading to enhanced engraftment and sustained function in a transplantation model. The study suggests that this technique could have implications for both autologous and allogeneic islet transplantation. [Extracted from the article] |
