Study Findings on Experimental Autoimmune Encephalomyelitis Are Outlined in Reports from State University of Campinas (UNICAMP) (Dimethyl fumarate modulates the regulatory T cell response in the mesenteric lymph nodes of mice with experimental...).

Předmět:	REGULATORY T cells DIMETHYL fumarate AUTOIMMUNE diseases LYMPH nodes CENTRAL nervous system infections ENCEPHALOMYELITIS
Zdroj:	Drug Week; 5/24/2024, p2400-2400, 1p
Abstrakt:	A recent study conducted by researchers at the State University of Campinas (UNICAMP) in Brazil has found that the drug dimethyl fumarate (DMF) can reduce the severity of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). DMF is commonly used to treat relapsing-remitting MS. The study showed that DMF treatment led to an increase in both proinflammatory and anti-inflammatory mechanisms, as well as an increase in regulatory T cells and anti-inflammatory cytokines in the gut draining lymph nodes of mice with EAE. These findings suggest that the gut is the primary site of action for DMF and may contribute to its effectiveness in reducing disease severity in MS patients. [Extracted from the article]
Databáze:	Complementary Index
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