| Abstrakt: |
A study conducted at the University of New South Wales Sydney investigated the use of micelle dynamics to enhance the uptake of cyclosporine in hyaluronic acid-contact lenses for the management of dry eye. The researchers found that Pluronic F127 micelles demonstrated superior properties compared to Tween 80 micelles, including higher drug uptake, improved lens properties, and sustained release of cyclosporine. Animal studies also showed that wearing the micelle-laden lenses resulted in lower levels of IL-6 compared to cyclosporine eye drops. These findings suggest that micelle-laden contact lenses could be a promising alternative to eye drops for dry eye management. [Extracted from the article] |
