Research from University of Belgrade in the Area of Biomarkers Published (Phosphorylated neurofilament heavy chain in cerebrospinal fluid and plasma as a Nusinersen treatment response marker in childhood-onset SMA individuals from Serbia).

Předmět:	CEREBROSPINAL fluid CYTOPLASMIC filaments BIOMARKERS SPINAL muscular atrophy
Zdroj:	Drug Week; 5/24/2024, p1803-1803, 1p
Abstrakt:	A study conducted by researchers at the University of Belgrade in Serbia explored the use of phosphorylated neurofilament heavy chain (pNF-H) as a biomarker for spinal muscular atrophy (SMA) treatment response. The study involved 29 individuals with childhood-onset SMA who were treated with Nusinersen. The researchers found that CSF pNF-H levels were significantly higher in untreated SMA individuals compared to controls, and monitoring CSF pNF-H levels could indicate short-term treatment response in childhood-onset SMA individuals. Plasma pNF-H levels may be a suitable measure for disease progression and treatment response in types 1 and 2 SMA, but not in type 3. [Extracted from the article]
Databáze:	Complementary Index
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