Latent Tuberculosis Infection Management in Solid Organ Transplantation Recipients: A National Snapshot.
| Autor: | Alpaydın, Aylin Özgen, Turunç, Tuba Yeter, Avkan-Oğuz, Vildan, Öner-Eyüboğlu, Füsun, Tükenmez-Tigen, Elif, Güle Aydın, İmran Hasanoğlu6, Tezer-Tekçe, Yasemin, Şenbayrak, Seniha, Kızılateş, Filiz, Aypak, Adalet Altunsoy, Altunışık-Toplu, Sibel, Ergen, Pınar, Kurtaran, Behice, Taşbakan, Meltem Işıkgöz, Yıldırım, Ayşegül, Yıldız, Serkan, Çalışkan, Kenan, Ayvazoğlu, Ebru, Dulundu, Ender, Şeref Parlak, Ebru Şengül |
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| Předmět: |
RISK assessment
INTERFERON gamma release tests MEDICAL protocols TRANSPLANTATION of organs tissues etc. PATIENTS ISONIAZID ORGAN donor registries FISHER exact test RETROSPECTIVE studies DESCRIPTIVE statistics MANN Whitney U Test CHI-squared test PRE-tests & post-tests TUBERCULIN test RESEARCH methodology MEDICAL screening DATA analysis software LATENT tuberculosis DEMOGRAPHY SENSITIVITY & specificity (Statistics) DISEASE risk factors SYMPTOMS |
| Zdroj: | Thoracic Research & Practice; May2024, Vol. 25 Issue 3, p130-135, 6p |
| Abstrakt: | OBJECTIVE: Latent tuberculosis infection (LTBI) screening is strongly recommended in the pre-transplant evaluation of solid organ transplant (SOT) recipients, although it remains inadequate in many transplant centers. We decided to investigate pre-transplant TB risk assessment, LTBI treatment, and registry rates in Türkiye. MATERIAL AND METHODS: Adult SOT recipients who underwent tuberculin skin test (TST) and/or interferon-gamma release test (IGRA) from 14 centers between 2015 and 2019 were included in the study. An induration of ≥5 mm on TST and/or probable/positive IGRA (QuantiFERON-TB) was considered positive for LTBI. Demographic features, LTBI screening and treatment, and pre-/post-transplant TB history were recorded from the electronic database of transplantation units across the country and pooled at a single center for a unified database. RESULTS: TST and/or IGRA were performed in 766 (33.8%) of 2266 screened patients most of whom were kidney transplant recipients (n = 485, 63.4%). LTBI screening test was positive in 359 (46.9%) patients, and isoniazid was given to 203 (56.5%) patients. Of the patients treated for LTBI, 112 (55.2%) were registered in the national registry, and 82 (73.2%) completed the treatment. Tuberculosis developed in 6 (1.06%) of 563 patients who were not offered LTBI treatment. CONCLUSION: We determined that overall, only one-third of SOT recipients in our country were evaluated in terms of TB risk, only 1 of the 2 SOT recipients with LTBI received treatment, and half were registered. Therefore, we want to emphasize the critical importance of pretransplant TB risk stratification and registration, guided by revised national guidelines. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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