| Autor: |
Zhong, Shuyi, Ng, Tiffany W Y, Skowronski, Danuta M, Iuliano, A Danielle, Leung, Nancy H L, Perera, Ranawaka A P M, Ho, Faith, Fang, Vicky J, Tam, Yat Hung, Ip, Dennis K M, Havers, Fiona G, Fry, Alicia M, Aziz-Baumgartner, Eduardo, Barr, Ian G, Peiris, Malik, Thompson, Mark G, Cowling, Benjamin J |
| Předmět: |
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| Zdroj: |
Journal of Infectious Diseases; 5/15/2024, Vol. 229 Issue 5, p1451-1459, 9p |
| Abstrakt: |
Background Annual influenza vaccination is recommended for older adults but repeated vaccination with standard-dose influenza vaccine has been linked to reduced immunogenicity and effectiveness, especially against A(H3N2) viruses. Methods Community-dwelling Hong Kong adults aged 65–82 years were randomly allocated to receive 2017–2018 standard-dose quadrivalent, MF59-adjuvanted trivalent, high-dose trivalent, and recombinant-HA quadrivalent vaccination. Antibody response to unchanged A(H3N2) vaccine antigen was compared among participants with and without self-reported prior year (2016–2017) standard-dose vaccination. Results Mean fold rise (MFR) in antibody titers from day 0 to day 30 by hemagglutination inhibition and virus microneutralization assays were lower among 2017–2018 standard-dose and enhanced vaccine recipients with (range, 1.7–3.0) versus without (range, 4.3–14.3) prior 2016–2017 vaccination. MFR was significantly reduced by about one-half to four-fifths for previously vaccinated recipients of standard-dose and all 3 enhanced vaccines (β range,.21–.48). Among prior-year vaccinated older adults, enhanced vaccines induced higher 1.43 to 2.39-fold geometric mean titers and 1.28 to 1.74-fold MFR versus standard-dose vaccine by microneutralization assay. Conclusions In the context of unchanged A(H3N2) vaccine strain, prior-year vaccination was associated with reduced antibody response among both standard-dose and enhanced influenza vaccine recipients. Enhanced vaccines improved antibody response among older adults with prior-year standard-dose vaccination. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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