Manual therapy and exercise effects on inflammatory cytokines: a narrative overview.
| Autor: | Cook, Chad E., Keter, Damian, Cade, William Todd, Winkelstein, Beth A., Reed, William R. |
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| Předmět: |
FEAR
MUSCULOSKELETAL pain IRRITABLE colon MULTIPLE sclerosis EXERCISE therapy MANIPULATION therapy TREATMENT effectiveness ANXIETY GRANULOCYTE-macrophage colony-stimulating factor PSYCHOLOGICAL stress CYTOKINES INFLAMMATION SLEEP quality CHRONIC fatigue syndrome INTERLEUKINS TUMOR necrosis factors DIET MENTAL depression ASTHMA EVALUATION |
| Zdroj: | Frontiers in Rehabilitation Sciences; 2024, p1-11, 11p |
| Abstrakt: | Background: Matching disease and treatment mechanisms is a goal of the Precision Medicine Initiative. Pro- and anti-inflammatory cytokines (e.g., Tumor Necrosis Factor-alpha, Transforming Growth Factor-beta, and Interleukin-2, 10, and 12) have gained a significant amount of interest in their potential role in persistent pain for musculoskeletal (MSK) conditions. Manual therapy (MT) and exercise are two guideline-recommended approaches for treating MSK conditions. The objective of this narrative overview was to investigate of the effects of MT and exercise on pro- and anti-inflammatory cytokines and determine the factors that lead to variability in results. Methods: Two reviewers evaluated the direction and variabilities of MT and exercise literature. A red, yellow, and green light scoring system was used to define consistencies. Results: Consistencies in responses were seen with acute and chronic exercise and both pro- and anti-inflammatory cytokines. Chronic exercise is associated with a consistent shift towards a more anti-inflammatory cytokine profile (Transforming Growth Factor-beta, and Interleukin-2 and 13, whereas acute bouts of intense exercise can transiently increase pro-inflammatory cytokine levels. The influence of MT on cytokines was less commonly studied and yielded more variable results. Conclusion: Variability in findings is likely related to the subject and their baseline condition or disease, when measurement occurs, and the exercise intensity, duration, and an individual's overall health and fitness. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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