| Autor: |
Tan, Brendan, Tamanyan, Knarik, Walter, Lisa, Nixon, Gillian M., Davey, Margot J., Ditchfield, Michael, Horne, Rosemary S. C. |
| Předmět: |
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| Zdroj: |
Journal of Sleep Research; May2024, Vol. 33 Issue 3, p1-12, 12p |
| Abstrakt: |
Summary: This paper investigated cortical thickness and volumetric changes in children to better understand the impact of obstructive sleep disordered breathing (SDB) on the neurodevelopment of specific regions of the brain. We also aimed to investigate how these changes were related to the behavioral and cognitive deficits observed in the condition. Neuroimaging, behavioral, and sleep data were obtained from 30 children (15 non‐snoring controls, 15 referred for assessment of SDB) aged 7 to 17 years. Gyral‐based regions of interest were identified using the Desikan‐Killiany atlas. Student's t‐tests were used to compare regions of interest between the controls and SDB groups. We found that the cortical thickness was significantly greater in the right caudal anterior cingulate and right cuneus regions and there were volumetric increases in the left caudal middle frontal, bilateral rostral anterior cingulate, left, right, and bilateral caudate brain regions in children with SDB compared with controls. Neither cortical thickness nor volumetric changes were associated with behavioral or cognitive measures. The findings of this study indicate disruptions to neural developmental processes occurring in structural regions of the brain; however, these changes appear unrelated to behavioural or cognitive outcomes. [ABSTRACT FROM AUTHOR] |
| Databáze: |
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