Lower cognitive reserve is related to worse working memory performance in older adults after mTBI. An ERP study.
| Autor: | Balart-Sánchez, SA, Bittencourt, M., van der Naalt, J, Maurits, N.M. |
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| Předmět: |
COGNITION disorder risk factors
RISK assessment REPEATED measures design STATISTICAL models PEARSON correlation (Statistics) RESEARCH funding TASK performance T-test (Statistics) DATA analysis ACADEMIC medical centers EVOKED potentials (Electrophysiology) ELECTROENCEPHALOGRAPHY DESCRIPTIVE statistics MANN Whitney U Test CHI-squared test ANALYSIS of covariance GLASGOW Coma Scale ATTENTION LONGITUDINAL method CASE-control method CONVALESCENCE STATISTICS SHORT-term memory BRAIN injuries REACTION time DIGITAL image processing CEREBRAL dominance DATA analysis software COMPARATIVE studies ALGORITHMS REGRESSION analysis DISEASE complications OLD age |
| Zdroj: | Brain Injury; 2024, Vol. 38 Issue 7, p550-558, 9p |
| Abstrakt: | Older adults (OA) after mild traumatic brain injury (mTBI) have a high risk of developing persistent post-injury cognitive impairments. Lower pre-morbid cognitive reserve (CR) is increasingly investigated as a risk factor for cognitive dysfunction in OA. However, how CR protects against effects of mTBI at the brain level remains largely understudied. We examined 22 OA who sustained mTBI (mean 67.69 years, SD 5.11) in the sub-acute phase and 15 age- and CR-matched healthy OA (mean 68 years, SD 5.55) performing a three-level visual N-back task using electroencephalography. We calculated inverse efficiency scores of performance from accuracy and reaction times. Event-related potentials served as neurocognitive correlates of attentional (P2) and working memory (P3) processing. Overall, mTBI OA performed worse than healthy OA (p = 0.031). Lower CR generally decreased performance (p < 0.001). Furthermore, with increasing task difficulty, task performance was more affected by CR (p = 0.004). At the brain level, P2 amplitude was lower in mTBI OA than in healthy OA (p = 0.05). There was no clear effect of CR on P2 or P3 measures. As mTBI OA with lower CR performed worse on a working-memory task, lower CR may be a risk factor for worse recovery after mTBI in this group. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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