| Autor: |
Wikandari, Prima R., Herdyastuti, Nuniek, Tukiran, Dzulkarnain, Shod A. |
| Předmět: |
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| Zdroj: |
Tropical Journal of Natural Product Research; Apr2024, Vol. 8 Issue 4, p6858-6863, 6p |
| Abstrakt: |
The health-promoting components of single-bulb garlic are often enhanced by fermenting microorganisms during fermentation. Therefore, this research aimed to assess the antidiabetic effect of fermented single-bulb garlic (FSBG) using Lactobacillus plantarum B1765 on type 2 diabetes mellitus (T2DM) rats. The variables evaluated were peripheral blood glucose, venous blood glucose, and pancreatic β-cells. T2DM was induced in the experimental rats using a combination of a high-fat diet (HFD) and a low dose of streptozotocin (STZ). Antidiabetic effects of FSBG were compared with metformin, and the results showed that FSBG reduced peripheral blood glucose levels after 2-8 hours. In the longer term, 300 mg/kg of FSBG also significantly reduced venous blood glucose levels compared to metformin. The pancreatic β-cells were also significantly increased after 300 mg/kg FSBG oral doses. In conclusion, FSBG could be a potential source of antidiabetic constituents with good antidiabetic effects compared to conventional drugs such as metformin. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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