| Autor: |
Congyu Liao, Xiaozhi Cao, Iyer, Siddharth Srinivasan, Schauman, Sophie, Zihan Zhou, Xiaoqian Yan, Quan Chen, Zhitao Li, Nan Wang, Ting Gong, Zhe Wu, Hongjian He, Jianhui Zhong, Yang Yang, Kerr, Adam, Grill-Spector, Kalanit, Setsompop, Kawin |
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| Zdroj: |
Magnetic Resonance in Medicine; Jun2024, Vol. 91 Issue 6, p2278-2298, 16p |
| Abstrakt: |
Purpose: This study aims to develop a high-resolution whole-brain multiparametric quantitative MRI approach for simultaneous mapping of myelin-water fraction (MWF), T1, T2, and proton-density (PD), all within a clinically feasible scan time. Methods: We developed 3D visualization of short transverse relaxation time component (ViSTa)-MRF, which combined ViSTa technique with MR fingerprinting (MRF), to achieve high-fidelity whole-brain MWF and T1/T2/PD mapping on a clinical 3T scanner. To achieve fast acquisition and memory-efficient reconstruction, the ViSTa-MRF sequence leverages an optimized 3D tiny-golden-angle-shuffling spiral-projection acquisition and joint spatial-temporal subspace reconstruction with optimized preconditioning algorithm. With the proposed ViSTa-MRF approach, high-fidelity direct MWF mapping was achieved without a need for multicompartment fitting that could introduce bias and/or noise from additional assumptions or priors. Results: The in vivo results demonstrate the effectiveness of the proposed acquisition and reconstruction framework to provide fast multi-parametric mapping with high SNR and good quality. The in vivo results of 1mm- and 0.66 mm-isotropic resolution datasets indicate that the MWF values measured by the proposed method are consistent with standard ViSTa results that are 30× slower with lower SNR. Furthermore, we applied the proposed method to enable 5-min whole-brain 1 mm-iso assessment of MWF and T1/T2/PD mappings for infant brain development and for post-mortem brain samples. Conclusions: In this work, we have developed a 3D ViSTa-MRF technique that enables the acquisition of whole-brain MWF, quantitative T1, T2, and PD maps at 1 and 0.66mm isotropic resolution in 5 and 15min, respectively. This advancement allows for quantitative investigations of myelination changes in the brain. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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